LPAR-19

A forum where, year after year, some of the most renowned researchers in the areas of product innovations come to present cutting-edge results.

#Biomedical Innovation

Novel Medical Treatment Using Amplified Resonant Frequencies of Pathogens

We are surrounded by a whole variety of pathogenic organisms – mainly viruses and bacteria. Modern antibiotics are effective in some cases, but it is often a race against time before the bacterium adapts and the antibiotic becomes impotent.

It’s a war which we seem to be losing, made worse by people on drug regimes not continuing the treatment until the end of the course of medication so that some bacteria survive and become immune to the treatment. Furthermore, the …

#Food Management Innovation

Information Technology in the Food Industry

The use of Information Technology (IT) and technology is inevitable for any business in this era. Especially so for the food industry. As consumers find it so much easier to get any information about just about anything and become more tech-savvy, they get more and more demanding. They expect the best, quickest service but also expect a superior quality at a decent and attractive price. Technology and IT is expected for better quality products and services.

Cashless payment solutions (here: …

#Medical Research

Another Anti-CD20 Monoclonal in Clinical Trials

Anti-CD20 monoclonals are all the rage these days. Notwithstanding the recent adverse effects reports, Rituxan is the single most crucial discovery in the last decade for CLL patients. We’re keeping our fingers crossed that the FDA will approve the next in line contender for the anti-CD20 crown HuMax-CD20.

Cripes, it takes so darn long for new inventions to go through the clinical trials and regulatory process before we can hope to see them commercially available! Sometimes we get discouraged by …

#Bioinformatics Innovation

Sequence-based Ultra-Rapid Pathogen Identification (SURPI)

An ultra-rapid bioinformatics pipeline that uses state-of-the-art computational algorithms to analyze real-time next-generation sequencing (NGS) data for infectious pathogen detection and discovery.

SUGGESTED USES

  • Web-based interface and clients being charged to use the pipeline
  • Integration into existing bioinformatics suites
  • Coupling of SURPI analysis with the development of NGS-based clinical assay kits or platforms
  • Integration into existing Laboratory Information Management System (LIMS)
  • Support for genomics research in a variety of different fields, including clinical diagnostics, blood bank screening, purity and safety
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#Medical Research

ZAP-70 and IgVH Gene Mutation

Two prognostic indicators have become the focus of much discussion in recent months, ZAP-70 and IgVH mutation status. These two indicators, in combination with FISH analysis to pinpoint the chromosomal aberration that is at the root of the CLL, go a long way toward defining the risk category of the patient in question. We have discussed both ZAP-70 and IgVH in prior articles (What Type of CLL Do You Have?, Prognosis at Diagnosis, Prognostic Indicators).

But to tell the truth, …

#Biomedical Innovation

HDAC-8 Activation and Inhibition with Multiple Therapeutic Benefits

NDSU Scientists have developed a technology to activate or enhance inhibition of histone deacetylase-8 (HDAC-8). The technology is based on the ability of “activators” (N-acylthioureas) to bind directly to HDAC-8.

When provided alone, N-acylthioureas enhance normal substrate binding and have promise for treatment of Cornelia de Lang syndrome, some neuroblastomas, and other ‘smooth muscle contractility’ diseases.

When provided in combination with an HDAC-8 inhibitor, binding of N-acylthioureas to HDAC-8 strengthens the inhibitor activity. Through this mechanism, N-acylthioureas have promise in …